Gloves in a Bottle is a shielding lotion that helps keep irritants from bothering the skin, while keeping moisture in. I recently used a bottle of this over a period of a week and was pretty happy with it. I tend to have issues with my hands getting dry, especially when I use the computer a lot. I found that by using Gloves in a Bottle over time, my hands generally stayed comfortable and moisturized, especially when I reapplied it before using the computer keyboard and mouse. A similar product is Skin MD Natural.
You can purchase Gloves in a Bottle at Amazon.com or at various drugstores.